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对临床医生来说,理想的给药系统应使药物直接到达靶组织,并以较高浓度局限分布于靶部位,从而避免药物的全身效应.最直接的靶器官给药方式是由输入泵动脉给药.临床上已用这一方法治疗肝、骨盆、脑、口腔、咽以及上下肢恶性肿瘤,将细胞毒药物直接注入相应靶组织的供血动脉.靶器官导向动脉给药也用于抗血栓药物如链激酶,以溶解血栓.在实验研究中,该方法常用于确定药物的作用部位或专门影响某一特定组织的功能.
For clinicians, the ideal drug delivery system should allow the drug to reach the target tissue directly and confine it to the target site at a higher concentration, thus avoiding the systemic effects of the drug.The most direct target organ administration is by the infusion pump artery This method has been clinically used to treat liver, pelvic, brain, oral, pharyngeal and upper and lower extremity malignant tumors, the direct injection of cytotoxic drugs into the corresponding target tissue feeding artery. The target organ-directed arterial administration is also used for anti-thrombosis Drugs such as streptokinase to dissolve thrombus.In the experimental study, this method is often used to determine the role of the drug site or specifically affect the function of a particular tissue.