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蛋白质分子内精氨酸残基瓜氨酸化是蛋白质翻译后修饰作用之一,肽酰精氨酸脱亚氨酶(PAD)催化趋化因子发生瓜氨酸化反应,改变趋化因子的生物学活性,显示出PAD在体内免疫系统中的调节作用。
Citrullination of arginine residues in proteins is one of the post-translational modifications of proteins. Peptidyl arginine deiminase (PAD) catalyzes the citrullination of chemokines and changes the biological activity of chemokines , Shows the regulatory role of PAD in the body’s immune system.