TNF相关凋亡诱导配体(TNF related apoptosis inducing ligand,TRAIL)是TNF超家族的新成员。TRAIL与死亡受体结合,通过多种信号传导通路,能够诱导多种肿瘤细胞发生快速、高效的凋亡反应,而对正常细胞无明显毒性,成为近年来人们研究抗肿瘤治疗的热点。然而越来越多的研究证实并不是所有的肿瘤细胞都对TRAIL敏感,特别是那些高度恶性的肿瘤细胞,为克服肿瘤细胞对TRAIL的耐药性,提高 TNF related apoptosis inducing ligand (TRAIL) is a new member of TNF superfamily. TRAIL and death receptor binding, through a variety of signaling pathways, can induce rapid and efficient apoptosis of a variety of tumor cells, and no obvious toxicity to normal cells, which has become a hot spot in anti-cancer therapy in recent years. However, more and more studies confirm that not all tumor cells are sensitive to TRAIL, especially those highly malignant tumor cells. In order to overcome the tumor cell resistance to TRAIL,