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目的：探讨分析IgA肾病患者发生慢性肾功能不全的相关危险因素。方法随机选取我院于2007-2013年收治的134例IgA肾病患者，检测患者的血肌肝水平，按照检测结果分为肾功能正常组和肾功能不全者，通过比较分析两组患者的临床病历资料，探讨分析IgA肾病患者发生慢性肾功能不全的相关危险因素。结果与肾功能正常组相比，肾功能不全患者的男性、蛋白尿、高血压发生率、尿蛋白水平、血IgA等多项参数较高，有显著性差异（P ＜0．05），而免疫沉积物半定量分析显示肾功能正常者的IgG的沉积高于肾功能不全者，有极显著性差异（P ＜0．01），但病程长短以及IgA、IgM、C3、C4、C1q和Fg的沉积比两组间没有显著性差异（P ＞0．05）。结论影响肾功能的危险因素众多，以蛋白尿最高，其余依次为男性、高血压、高龄、血IgA等；病程的长短以及IgA、IgM、C3、C4、C1q和Fg的沉积比不是肾功能不全的相关危险因素。“,”Objective To investigate the analysis of risk factors of chronic renal failure in patients with IgA nephropathy.134 cases of IgA nephropathy were randomly selected in our hos-pital from 2007-2013 were detected in patients,serum creatinine levels,according to the test results are divided into normal renal function group and renalinsuf iciency,through comparative a-nalysis of clinical data of two patients,analysis on the related risk factors of chronic renal failure patients IgA nephropathy.Results compared with normal renal function group,patients with renal insuficiency of men,proteinuria,hypertension,urinary protein,blood levels of IgA parameters is higher,there was significant diference (P <0.05),and semi quantitative analysis showed thatthedepositionofimmunedepositsofnormalrenalfunctionofIgGishigherthanthatofrenalinsuficiency,therewasasignificantdiference(P 0.05).Conclusion many dangerous factors to afect kidney function,urine protein was highest,fol owed by the rest of the male,hypertension,age,blood IgA;course of disease and related risk deposition of IgA,IgM,C3,C4,C1q and Fg than not factors of renal dysfunc-tion.