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目的:观察恩丹西酮对顺铂化疗所致呕吐的疗效。方法:随机将186例恶性肿瘤患者分为两组。90例单用恩丹西酮(A组),96例恩丹西酮加地塞米松治疗(B组)。结果:对急性呕吐止吐有效率A、B组分别为85.6%和96.9%。结论:恩丹西酮加地塞米松可显著提高对急性呕吐止吐有效率(P<0.05),但对迟发性呕吐,两组止吐疗效无明显差异(P>0.05)。
Objective: To observe the effect of ondansetron on vomiting induced by cisplatin chemotherapy. Methods: 186 cases of malignant tumors were randomly divided into two groups. Ninety patients were ondansetron (group A) and 96 ondansetron plus dexamethasone (group B). Results: The effective rate of antiemetic for acute vomiting was 85.6% in group A and 96.9% in group B, respectively. Conclusion: Ondansetron plus dexamethasone can significantly improve the antiemetic efficacy of acute vomiting (P <0.05), but there is no significant difference between the two groups in the efficacy of delayed emesis (P> 0.05).