本文以胆碱能毒蕈碱受体阻滞剂阿托品来研究胆碱能神经递质对生长激素分泌的调节。10例健康成年男性由胰岛素低血糖诱发急性生长激素(GH)升高,注射阿托品后虽不能防止低血糖发生,但GH的升高受到抑制。注射后45′,60′,75′三时相及反应曲线下面积与对照日比均有显著差异。再加用甲氰咪呱后,60′,75′,90′GH 值及反应面积均显著低于对照日,但与单用阿托品相比无显著差别。 In this paper, cholinergic muscarinic receptor blocker atropine to study cholinergic neurotransmitter regulation of growth hormone secretion. In 10 healthy adult men, the acute growth hormone (GH) was induced by insulin hypoglycemia. Although the hypoglycemia was not prevented after atropine injection, the increase of GH was inhibited. After injection 45 ’, 60’, 75 ’three-phase and response curve area under the control of the ratio were significantly different. After adding cimetidine, the values ​​of 60 ’, 75’, 90’GH and reaction area were significantly lower than that of the control day, but no significant difference compared with the single atropine.