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目的:探讨MTMR3基因3’非翻译区(3’UTR)1670C>T多态性与胃癌发病的关联。方法:通过病例对照研究,采用聚合酶链式反应-限制性片段长度多态性方法检测500例胃癌患者和502例正常对照者MTMR3基因1670C>T位点的基因型,通过非条件Logistic回归,并校正了性别、年龄、吸烟、饮酒的影响,分析该位点与胃癌易感性的关系。结果:MTMR3基因1670C>T基因型分布在病例组和对照组均符合Hardy-Weinberg平衡(P>0.05)。经过年龄、性别、吸烟和饮酒状况校正的非条件logistic回归分析发现,与CC基因型患者相比,含有T等位基因的基因型(CT和TT)患者胃癌的发病风险增高(校正优势比=1.72,95%置信区间=1.36~2.16,P=3.99×10-5)。结论:MTMR3基因1670C>T多态性位点与胃癌发病存在显著性关联,1670T可能是胃癌发生的一个遗传危险因素。
Objective: To investigate the association between 1670C> T polymorphism of 3’UTR and MTMR3 gene in gastric cancer. Methods: The 1670C> T locus of MTMR3 gene in 500 patients with gastric cancer and 502 healthy controls were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in case-control study. By non-conditional Logistic regression, And corrected the influence of gender, age, smoking and drinking, and analyzed the relationship between the locus and the susceptibility to gastric cancer. Results: The 1670C> T genotype distribution of MTMR3 gene was in accordance with Hardy-Weinberg equilibrium (P> 0.05) in both cases and controls. Non-conditional logistic regression analysis adjusted for age, gender, smoking, and alcohol status found that patients with genotypes of the T allele (CT and TT) had a higher risk of developing gastric cancer than those with CC genotype (adjusted odds ratio = 1.72, 95% confidence interval = 1.36-2.16, P = 3.99 × 10-5). CONCLUSION: The 1670C> T polymorphism of MTMR3 gene is significantly associated with the development of gastric cancer. 1670T may be a genetic risk factor for gastric cancer.