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目的评价宫颈LSIL患者行HPV检测的临床意义,以便更好地指导LSIL患者的治疗。方法 2009年5月-2011年3月,到我院门诊行宫颈病变液基细胞学(TCT)检测提示LSIL的212例妇女,采用表面等离子谐振技术(SPR)检测HPV感染并分型,必要者行宫颈活组织病理检查,收集病理检查结果。运用SPSS16.0统计软件对数据进行分析。结果受试人群HPV感染率为73.11%。24种HPV亚型中检出21种,受试人群中感染率排名前3位的是16、58、33亚型。对细胞学提示LSIL的受试人群,SPR-HPV检测筛查CINⅡ及以上级别病变的敏感度为98.78%。结论对细胞学检查提示LSIL的人群,HPV检测可有效检出宫颈CINⅡ及以上级别病变。
Objective To evaluate the clinical significance of HPV testing in patients with cervical LSIL in order to better guide the treatment of LSIL patients. Methods From May 2009 to March 2011, cervical smear-based cytology (TCT) detection in our hospital suggested that 212 women with LSIL were detected by surface plasmon resonance (SPR) Cervical biopsy pathology, collection of pathological findings. Using SPSS16.0 statistical software to analyze the data. Results The prevalence of HPV in the test subjects was 73.11%. Twenty-one out of 24 HPV subtypes were detected, and the top three in the population tested were 16,58,33 subtypes. The sensitivity of SPR-HPV testing to CINⅡ and above was 98.78% in the cytology-prompted LSIL subjects. Conclusion The results of cytological examination suggest that LSIL population, HPV detection can effectively detect cervical CIN Ⅱ and above lesions.