磷酸羟基哌喹是第二军医大学研制成功的一种抗疟良药,治疗实验性矽肺和临床观察有较明显的效果。我们承本专题研究协作组的委托,进行重复验证。现将初步观察结果报告如下: 实验方法矽肺模型:选用180～220克雄性成年大白鼠,采用气管注入法染尘,每鼠染尘40毫克,一次分侧注入。所用的粉尘含游离siO_2 99％以上,颗粒直径小于5微米者占95％;重复实 Hydroxypipeoquine is an anti-malarial drug developed successfully by the Second Military Medical University and has obvious effects in the treatment of experimental silicosis and clinical observation. We undertake this project commissioned by the collaborative research team to conduct repeated verification. Preliminary observations are now reported as follows: Experimental Methods Silicosis model: 180 to 220 grams of male adult rats were selected by tracheal injection of dust, 40 mg of dust per mouse, a sub-injection. The dust used contains more than 99% of free siO_2, 95% of particles with diameter less than 5 μm;