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目的探讨早期维生素D干预治疗对儿童反复呼吸道感染的影响。方法 2~3岁儿童200例随机分为治疗组100例和对照组100例,对照组在2岁后停止补充维生素D,治疗组2岁后继续每天口服补充维生素D 400~800IU,观察随访1年,比较两组维生素D缺乏及反复呼吸道感染发生情况。结果治疗组维生素D缺乏儿童比例低于对照组(22.0%vs.26.0%),且反复呼吸道感染患病率低于对照组(15.0%vs.27.0%)(P<0.05)。结论儿童反复呼吸道感染的发病与血清维生素D水平相关,合理规范地补充维生素D是降低反复呼吸道感染的有效措施。
Objective To investigate the effect of early vitamin D intervention on recurrent respiratory tract infections in children. Methods 200 children aged 2 to 3 years old were randomly divided into treatment group (100 cases) and control group (100 cases). In the control group, vitamin D supplementation was stopped after 2 years of age. The treatment group continued oral supplementation with 400-800 IU of vitamin D daily after 2 years of observation. Year, compared two groups of vitamin D deficiency and recurrent respiratory tract infection. Results The proportion of children with vitamin D deficiency in the treatment group was lower than that of the control group (22.0% vs.26.0%), and the prevalence of recurrent respiratory infections was lower than that of the control group (15.0% vs.27.0%, P <0.05). Conclusions The incidence of recurrent respiratory tract infections in children is related to the level of serum vitamin D. The rational and regular vitamin D supplementation is an effective measure to reduce recurrent respiratory tract infections.