论文部分内容阅读
目的观察双环醇联合拉米夫定治疗慢性乙型肝炎的治疗效果。方法180例慢性乙型肝炎患者随机分为三组。双环醇组用双环醇(北京协和药厂)口服25mg/次,3次/d,疗程6个月;拉米夫定组用拉米夫定100mg口服,每日1次,疗程6个月,联合组双环醇和拉米夫定同时应用。结果治疗结束时,联合组肝功复常率与双环醇组相近,高于拉米夫定组;HBVDNA阴转率联合组76.7%与拉米夫定组70.0%相近,高于双环醇组28.3%;HBeAg阴转率联合组43.3%高于双环醇组25.0%及拉米夫定组11.7%。结论双环醇联合拉米夫定治疗慢性乙型肝炎有协同作用,优于单一用药。
Objective To observe the therapeutic effect of bicyclol combined with lamivudine on chronic hepatitis B. Methods 180 patients with chronic hepatitis B were randomly divided into three groups. Bicyclol group with bicyclol (Peking Union Medical College) oral 25mg / time, 3 times / d, treatment for 6 months; lamivudine group with lamivudine 100mg orally, once daily for 6 months, Combination group bicyclol and lamivudine at the same time. Results At the end of treatment, the rate of abnormal liver function in the combined group was similar to that in the bicyclic alcohol group and higher than that in the lamivudine group. The ratio of negative conversion rate of HBVDNA was 76.7% in the combined group and 70.0% in the lamivudine group, %; 43.3% in HBeAg negative conversion group was higher than 25.0% in bicyclic alcohol group and 11.7% in lamivudine group. Conclusions Bicyclol combined with lamivudine has a synergistic effect on chronic hepatitis B, which is better than single administration.