新生儿溶血病(hemolytic disease of the newborn,HDN)是由于孕妇和新生儿之间血型不合而产生的免疫性疾病,是造成新生儿病理性黄疸的常见原因之一,最常见的是由IgG抗-D引起,IgG抗-E次之。本例Rh(D)阴性待产妇产前血型血清学检测出血清中存在IgM和IgG性质混合的抗-D抗体、IgG性质抗-E抗体,其中IgG抗-D、抗-E抗体导致新生儿发生Rh系统HDN,现报告如 Hemolytic disease of the newborn (HDN) is an autoimmune disease caused by the incompatibility of blood type between pregnant women and newborns. It is one of the common causes of neonatal pathological jaundice. The most common cause is caused by IgG -D, IgG anti-E second. This case of Rh (D) -negative pregnant women prenatal blood group serological detection of serum IgM and IgG mixed anti-D antibody, IgG anti-E antibody, IgG anti-D, anti-E antibody lead to newborns Rh system HDN occurs, as reported now