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为了考核人工肝脏辅助装置的疗效,建立较为理想的急性肝功能衰竭动物模型非常重要。自1968年 Keppler 首先采用 D-氨基半乳糖(GalN)腹腔内注射引起重度急性肝坏死及肝性昏迷后,由于其病理变化酷似
In order to evaluate the efficacy of artificial liver aids, it is very important to establish an ideal animal model of acute liver failure. Since 1968 Keppler first used D-galactosamine (GalN) intraperitoneal injection caused severe acute liver necrosis and hepatic coma, due to its pathological changes resembles