A comparative review of HLA associations with hepatitis Band C viral infections across global popula

来源 :World Journal of Gastroenterology | 被引量 : 0次 | 上传用户:lwlw02
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC). Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV infections worldwide. The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in relation to susceptibility, viral persistence and treatment. Extensive literature search was conducted to explore the HLA associations in HBV and HCV infections reported across global populations over the past decade to understand the knowledge status, weaknesses and strengths of this information in different ethnic populations. HLA DR13 is consistently associated with HBV clearance globally. HLADRB1*11/*12 alleles and DQB1*0301 are associated with HBV persistence but with HCV clearance worldwide. Consistent association of DRB1*03 and *07 is observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population. HLA DR13 is protective for vertical HBV and HCV transmission in Chinese and Italian neonates, but different alleles are associated with their susceptibility in these populations. HLA class Ⅰmolecule interactions with Killer cell immunoglobulin like receptors (KIR) of natural killer (NK) cells modulate HCV infection outcome via regulating immune regulatory cells and molecules. HLA associations with HBV vaccination, interferon therapy in HBV and HCV, and with extra hepatic manifestations of viral hepatitis are also discussed. Systematic studies in compliance with global regulatory standards are required to identify the HLA specific viral epitope, stage specific T cell populations interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations. These studies would facilitate stage specific therapeutic strategies for clearance of HBV and HCV infections or co-infections across global populations and aid in identification of HBV-HCV combined vaccine. HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations. Hepatitis B (HBV) and hepatitis C (HCV) viral infection or co-infection leads to risk of development of chronic infection, cirrhosis and hepatocellular carcinoma (HCC). Immigration and globalization have added to the challenges of public health concerns regarding chronic HBV and HCV aids worldwide. The aim of this study is to review existing global literature across ethnic populations on HBV and HCV related human leukocyte antigen (HLA) associations in in to to susceptibility, viral persistence and treatment. Extensive literature search conducted to explore the HLA associations in HBV and HCV infections reported across global populations over the past decade to understand the knowledge status, weaknesses and strengths of this information in different ethnic populations. HLADRB1 * 11 / * 12 alleles and DQB1 * 0301 are associated with HBV persistence but with HCV clearance worldwide. Consistent association of DRB1 * 03 and HLA-07 are observed with HCV susceptibility and non-responsiveness to HBV vaccination across the population. HLA DR13 is protective for vertical HBV and HCV transmission in Chinese and Italian neonates, but different alleles are associated with their susceptibility in these populations. HLA class Imolecule interactions with Killer cell immunoglobulin like receptors (KIR) of natural killer (NK) cells modulate HCV infection outcome via regulating immune regulatory cells and molecules. HLA associations with HBV vaccination, interferon therapy in HBV and HCV, and with extra hepatic manifestations of viral hepatitis are also discussed. Systematic studies in compliance with global regulatory standards are required to identify the HLA specific viral epitopes, stage specific cell line interacting with different HLA alleles during disease progression and viral clearance of chronic HBV or HCV infections among different ethnic populations. These studies would facilitate stage specific t herapeutic strategies for clearance of HBV and HCV infections or co-infections across global populations and aid in identification of HBV-HCV combined vaccine. HLA associations of chronic HBV or HCV development with confounding host factors including alcohol, drug abuse, insulin resistance, age and gender are lacking and warrant detailed investigation across global populations.
其他文献
国家民爆质检中心复查取得好成绩1991年5月10日至12日由国家技术监督局、中国计量科学院、兵器工业总公司、江苏省标准局管理部门和专家组成的审查组,对南京理工大学承担的“国家民用爆
在我很小的时候,曾经有一片属于自己的天地,那是一块废弃了的老园子。曾经有人住在这里,可是后来那户人家搬走了,房子却留在了这里。几经风雨,房顶都垮塌了,老园子里长满了一
由於歷史原因,日本軍用技術的發展受到諸多限制。雖然日本依靠按許可證生產美國先進武器裝備的辦法使其武器裝備質量保持較高的水平,但對外國的依赖却成為一個重大的缺陷。
脑卒中是神经系统的常见疾病,它是一种严重危害人类健康的疾病,具有发病率高、死亡率高、致残率高、复发率高等临床特点,因此,如何早期诊断、早期治疗脑卒中,以降低死亡率和
休斯/雷锡恩公司参加美国SAM面空导弹计划投标休斯公司与雷锡恩公司已参与美军军级SAM面空导弹计划的投标,该导弹计划将成为美国与法、德联合生产中程增程型防空系统(MEADS)的基础。这些公司
湖北大冶市49岁农村教师朱幼芳,3年前患遗传性脊髓小脑性共济失调,行走、站立、抬手都很吃力,但她仍坚持扯着“拉力绳”完成一堂堂教学。她的父亲也是一名教师,患该病后坚守
“家里种了70多亩砂糖桔,去年每亩产果1万斤左右,每斤能卖到5块多钱,收入还可以。”桂林市荔浦县修仁镇大榕村柘村屯村民陈琴说,自己种植砂糖桔多年,种植规模由小扩大,一步一
这是一个世人关注的日子。1980年5月18日,我国首次成功地进行了“东风五号”洲际导弹运载火箭的发射试验,国际“热点”立即聚在了南太平洋的海空。为了警戒落区,保护数据舱
日本为获得其头2架以波音767为平台的机载警戒和控制系统(AWACS)已签订了2项合同,总额达8.4亿美元.这2架E-767飞机拟于1998年3月交付.据说日本正打算至少再买2架这种飞机.已
StudyonMilitarySoftwareQualitySUNXiangdong(TheFourthInstituteofEprao,Mao4,QingheBuilding,Beijing100085)Abstract:Inthispaper,a... Study on Military Software of Siang Xiangdong (The Fourth Institute of Erara, Mao4, Qinghe Building, Beijing100085) Abstract:
期刊