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目的探讨乌司他丁对重型颅脑损伤患者血清C-反应蛋白(CRP)的影响以及预防应激性溃疡的效果。方法将64例重型颅脑损伤患者按照随机原则分为对照组和研究组,每组各32例。对照组患者接受常规治疗,研究组患者在对照组患者治疗基础上加用乌司他丁。比较两组患者治疗后血清CRP水平变化以及应激性溃疡的发生率。结果治疗前两组间CRP水平[分别为(39.6±8.4)mg/L vs(38.4±9.2)mg/L无明显差异(P>0.05),治疗后两组患者CRP水平[分别为(22.5±6.3)mg/L vs(11.5±4.6)mg/L]均明显降低,且研究组患者CRP水平降低更为明显,差异均有统计学意义(P<0.05)。研究组患者应激性溃疡发生率明显低于对照组患者,差异有统计学意义(56.3%vs 78.1%,χ2=6.825,P<0.05)。结论乌司他丁能够明显降低重型颅脑损伤患者血清CRP水平,减少应激性溃疡的发生率,值得在临床中推广应用。
Objective To investigate the effect of ulinastatin on serum C-reactive protein (CRP) and the prevention of stress ulcer in patients with severe craniocerebral injury. Methods 64 patients with severe craniocerebral injury were randomly divided into control group and study group, with 32 cases in each group. Patients in the control group received routine treatment, and patients in the study group received ulinastatin on the basis of treatment in the control group. The changes of serum CRP level and the incidence of stress ulcer after treatment in both groups were compared. Results There was no significant difference in CRP levels between the two groups before treatment (39.6 ± 8.4 mg / L vs 38.4 ± 9.2 mg / L, respectively; P> 0.05). After treatment, CRP levels in both groups were (22.5 ± 6.3) mg / L vs (11.5 ± 4.6) mg / L], and the reduction of CRP in the study group was more significant with statistical significance (P <0.05). The incidence of stress ulcer in study group was significantly lower than that in control group (56.3% vs 78.1%, χ2 = 6.825, P <0.05). Conclusion Ulinastatin can significantly reduce serum CRP levels in patients with severe craniocerebral injury and reduce the incidence of stress ulcer, which is worth popularizing in clinic.