论文部分内容阅读
子宫内膜容受性是指母体子宫内膜对胚泡的接受能力。子宫内膜的形态学及相关因子表达伴随子宫内膜容受性发生变化,如胞饮突的出现、白血病抑制因子(leukemia inhibitory factor,LIF)、白介素-1(interleukin-1,IL-1)、整合素、选择素、胰岛素样生长因子(insulin-like growth factors,IGF)、前列腺素(prostaglandin,PG)、降钙素、基质金属蛋白酶(matrix metalloproteinases,MMPs)、组织金属蛋白酶抑制剂(tissue inhibitor of matrix metalloproteinases,TIMPs)、同源框基因(HOA基因)等蛋白和基因表达水平的变化。这些均可作为子宫内膜容受性不同时空的标志物,研究这些标志物不仅能够很好地监测子宫内膜容受性,而且能针对性地改善子宫内膜容受性,有助于提高胚胎着床率。
Endometrial receptivity refers to the ability of the mother’s endometrium to accept blastocysts. The expression of endometrial morphology and related factors is associated with changes in endometrial receptivity, such as the appearance of pinopodes, the expression of leukemia inhibitory factor (LIF), interleukin-1 (IL-1) , Integrins, selectins, insulin-like growth factors (IGFs), prostaglandin (PG), calcitonin, matrix metalloproteinases (MMPs), tissue tissue inhibitor of metalloproteinases inhibitor of matrix metalloproteinases (TIMPs), homeobox gene (HOA gene) and other protein and gene expression changes. These can be used as a marker of endometrial receptivity in different spatiotemporal areas. The study of these markers can not only monitor the endometrial receptivity well, but also improve the endometrial receptivity and improve the endometrial receptivity Embryo implantation rate.