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目的探讨非高密度脂蛋白胆固醇(非HDL-C)与冠状动脉病变严重程度的关系。方法选取内蒙古民族大学第二临床医学院心内科2014年6月—2015年6月经选择性冠脉造影诊断为冠心病的住院患者为研究对象,以同期同科非CHD患者为对照组,根据冠状动脉造影结果将患者分为CHD组(A组)与对照组(B组),按Gensini积分分为三组轻度A1≤16(n=82)、中度17≤A2≤40(n=78)、重度A3>40(n=82);按病变累及冠脉支数分为单支病变组n1(n=110)、双支病变组n2(n=70)、三支病变组n3(n=62),收集各组临床一般资料、生化资料和冠状动脉造影结果,按照公式非HDL-C=TC-HDL计算非HDL-C值,并进行统计学分析。结果 (1)与B组相比,A组高血压病史比例、糖尿病病史比例、年龄、TC、HDL-C、非HDL-C、TG、UA、Scr、Fig水平明显升高,差异有统计学意义(P<0.05)。(2)在A1、A2、A3组,TC、非HDL-C、UA随病变程度加重呈升高趋势,但差异无统计学意义;n1,n2.n3组TC、非HDL-C水平随着病变累及支数增加而增加,并且有统计学意义(P<0.05)。(3)Spearman等级相关分析显示:TC、非HDL-C、TG、UA、LP(a)与Gensini积分呈正相关。结论非HDL-C与CHD关系密切,可作为CHD发病风险的一项预测指标,并且与单独一项血脂指标对比,对CHD患者的冠状动脉病变严重程度有较好的相关性。
Objective To investigate the relationship between non-high density lipoprotein cholesterol (non-HDL-C) and the severity of coronary artery disease. Methods The hospitalized patients with coronary heart disease diagnosed as coronary heart disease by selective coronary angiography from June 2014 to June 2015 were selected as the study subjects in the Second Clinical Medical College of Inner Mongolia University for Nationalities from June 2014 to June 2015. According to the coronary The results of arteriography were divided into three groups: CHD group (group A) and control group (group B). According to the Gensini score, the patients were divided into three groups of mild A1≤16 (n = 82), moderate 17≤A2≤40 ), Severe A3> 40 (n = 82) .According to the number of lesions involved coronary artery, the patients were divided into single vessel disease group n1 (n = 110), double vessel disease group n2 = 62). The general clinical data, biochemical data and coronary angiography results of each group were collected. The non-HDL-C values were calculated according to the formula of non-HDL-C = TC-HDL and statistically analyzed. Results Compared with group B, the proportion of history of hypertension, the history of diabetes, age, TC, HDL-C, non-HDL-C, TG, UA, Scr and Fig in group A were significantly higher than those in group B Significance (P <0.05). (2) The TC, non-HDL-C and UA in groups A1, A2 and A3 increased with the severity of the disease, but the difference was not statistically significant. The level of TC and non-HDL-C in group n1 and n2.n3 increased with Lesions involving the increase in the count increased, and have statistical significance (P <0.05). (3) Spearman rank correlation analysis showed that TC, non-HDL-C, TG, UA, LP (a) were positively correlated with Gensini score. Conclusion Non-HDL-C is closely related to CHD, which can be used as a predictor of the risk of CHD. Compared with a single blood lipid index, non-HDL-C has a good correlation with the severity of coronary lesions in patients with CHD.