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目的探讨神经节苷脂(GM-1)治疗新生儿缺氧缺血性脑病(HIE)的临床疗效。方法将87例HIE患儿随机分成二组。对照组给予常规治疗,包括吸氧止惊、降血压、控制血糖、纠酸及电解质紊乱等。治疗组在常规治疗基础上给予GM-1静脉注射,观察比较两组患儿的治疗效果。结果治疗组总有效率显著高于对照组,差异有统计学意义(P<0.01)。结论 GM-1治疗HIE有一定疗效。
Objective To investigate the clinical efficacy of ganglioside (GM-1) in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE). Methods 87 HIE children were randomly divided into two groups. Control group given conventional treatment, including oxygen shock, lowering blood pressure, blood sugar control, acid correction and electrolyte disorders. The treatment group was given intravenous injection of GM-1 on the basis of routine treatment, and the therapeutic effects of the two groups were observed and compared. Results The total effective rate of the treatment group was significantly higher than that of the control group, the difference was statistically significant (P <0.01). Conclusion GM-1 treatment of HIE has a certain effect.