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不同水化状态(对照组、速尿组和水负荷组)的大鼠在模拟5000m和8000m高原,经历48h后测定肺、脑含水量。结果表明:一定程度的水负荷可增加模拟高原时肺和大脑皮层含水量。模拟5000m高原时的肺血管外含水量较模拟8000m高原时高。脑含水量增加主要发生在大脑皮层,8000m高原时增加更为显著。速尿可降低模拟高原时肺和脑的含水量。本实验支持进入高原的最初数日,肺水肿和脑水肿同时发生的假说,这是急性高山病过程中两个重要的组成成分。
Rats in different hydration states (control group, furosemide group and water load group) were used to simulate the 5000m and 8000m plateau, and the lung and brain water contents were measured after 48h. The results showed that: a certain degree of water load can increase the water content in the lung and cerebral cortex when simulated plateau. Pulmonary extravascular water content at 5000m plateau was higher than that of simulated 8000m plateau. Brain water content increased mainly in the cerebral cortex, 8000m plateau increased more significantly. Furosemide reduces the water content of the lungs and brain when simulating altitude sickness. This experiment supports the hypothesis that simultaneous occurrence of pulmonary edema and cerebral edema occurred on the first few days into the plateau, which are two important components in the process of acute mountain sickness.