体外试验已证实心得安为人体精子活动的强力抑制剂,在小鼠体内的试验也证明了这一点。临床研究认为,从月经的最后一天至下一个月经周期的第一天每晚将80mg普通心得安片植入阴道,可使妊娠率降至3～4%妇女年。为进一步评价其安全有效性,作者对6名健康未孕妇女进行了研究。研究在月经周期的1～21天进行,用子宫托尽可能深地将80mg心得安片植入阴道内,在给药前后记录仰卧位与直立位的血压、脉率及1秒钟内用力呼气量(FEV_1),并用高效液相色谱法测定给药前和给药后不同时间的心得安血浆浓度。另外又对其中4名妇女测定了口服心得安后的血浆浓度。结果,6名妇女未见有阴道刺激或其它症状,阴道感觉未受影响,无体位症状、气喘或哮鸣。植入心得安后在2,4,6和8小时的仰卧位收缩压和第8小时直立位收缩压下降有统计学的显著性(P<0.05),但对舒张医无影响。仰卧位与直立位脉压和FEV_1也 In vitro tests have confirmed that propranolol is a potent inhibitor of sperm motility in humans, as evidenced by experiments in mice. Clinical studies suggest that 80 mg of normal propolis will be implanted into the vagina nightly from the last day of menstruation to the first day of the next menstrual cycle, reducing the pregnancy rate to 3 to 4% of women’s years. To further evaluate its safety and efficacy, the authors studied 6 healthy pregnant women. Study in the menstrual cycle of 1 to 21 days, with pessary as much as possible deep into the vaginal implant 80mg, supine position and vertical position before and after recording the blood pressure, pulse rate and force within 1 second Volume of plasma (FEV_1), and plasma concentrations of propranolol at different times before and after administration were determined by high performance liquid chromatography. In addition, four of the women also measured the plasma concentrations of oral propranolol. As a result, 6 women had no vaginal irritation or other symptoms, vaginal sensations were unaffected, no asymptomatic symptoms, asthma or wheezing. Systolic blood pressure at supine position at 2, 4, 6, and 8 hours and reduction of systolic blood pressure at 8 hours after implantation were statistically significant (P <0.05), but no effect on diastolic. Supine position with orthostatic pulse pressure and FEV_1 also