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目的探讨代谢综合征(MS)子代在青春晚期糖脂代谢、抗氧化酶活性、总抗氧化能力与健康人子代的差异,为进一步探讨代谢综合征的发病机理提供参考。方法采用病例对照研究,对30例代谢综合征患者子代和74例健康人子代进行体格检查,包括身高、体质量、腰围(WC)和血压(BP)、计算体质量指数(BMI)、腰围/身高(WHtR)、腰围/臀围(WHR),并检测血清空腹血糖(FPG)、血脂水平、总抗氧化能力(T-AOC)、超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性。结果 MS患者青春期子代的肥胖指标和血压水平(腰围、腰围身高比、腰臀比、舒张压值)及血脂异常率(低、高密度脂蛋白胆固醇率)均高于健康成人群的青春期子代(P值均<0.05),而SOD和GSH-PX活性显著低于对照组(P值均<0.01)。SOD和GSH-PX的活性与WC,WHtR,WHR,DBP呈显著负相关(P值均<0.05),与HDL-C呈显著正相关(P<0.05),SOD活性与DBP也呈显著负相关(P<0.05)。结论代谢综合征患者子代MS和MS相关组分异常检出率均高于正常人群子代,且抗氧化酶活性低于正常人群子代。抗氧化酶的活性与MS组分(肥胖、血脂异常)有显著相关性。
Objective To investigate the differences of glycometabolism, antioxidant enzyme activity, total antioxidant capacity and the offspring of healthy human progeny of the metabolic syndrome (MS) progeny in late adulthood, and to provide a reference for further exploring the pathogenesis of metabolic syndrome. Methods A case-control study was conducted on 30 offspring of children with metabolic syndrome and 74 healthy adults, including height, weight, waist circumference (WC) and blood pressure (BP), and body mass index (BMI) WHtR, WHR and serum fasting blood glucose (FPG), blood lipid level, total antioxidant capacity (T-AOC), superoxide dismutase (SOD) and glutathione Peroxidase (GSH-PX) activity. Results The obesity index and blood pressure (waist circumference, waist circumference ratio, waist-to-hip ratio, diastolic blood pressure) and dyslipidemia (low and high density lipoprotein cholesterol) in adolescent children with MS were higher than those in healthy adults (P <0.05), while the activity of SOD and GSH-PX was significantly lower than that of the control group (P <0.01). The activities of SOD and GSH-PX were negatively correlated with WC, WHtR, WHR and DBP (all P <0.05), and were positively correlated with HDL-C (P <0.05) (P <0.05). Conclusion The abnormal detection rates of MS and MS related components in offspring of MS patients were higher than those of normal population and the activities of antioxidant enzymes were lower than those of normal population. Antioxidant enzyme activity and MS components (obesity, dyslipidemia) have a significant correlation.