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目的探讨人工流产术前米索前列醇阴道放置以扩张宫颈的适宜剂量。方法将要求人流且符合标准的120名初孕妇随机分成3组,试验1组术前2h~4h阴道放置米索前列醇200ug,试验2组术前2h~4h阴道放置米索前列醇400ug,对照组术前不放置任何药物。结果(1)宫颈扩张情况阴道放置米索前列醇组(试验1组和试验2组)与对照组相比宫颈扩张差异具有统计学意义(P<0.05),且阴道放置米索前列醇400ug较200ug宫颈扩张效果更好(P<0.05):(2)阴道放置米索前列醇组手术时间、术中出血量均较对照组少,差异具有统计学意义(P<0.05),而手术并发症并无差别,试验1组与试验2组药物副作用亦无差别。结论人工流产术前阴道放置米索前列醇宫颈扩张效果好,且400ug为其适宜剂量,使用安全,值得推广。
Objective To investigate the appropriate dose of vaginal misoprostol for cervical dilatation before induced abortion. Methods A total of 120 primiparous pregnant women who required abortion and compliance with standards were randomly divided into three groups. Group 1 received 200ug of misoprostol vaginally from 2h to 4h before operation, and 400ug of misoprostol was intravaginally administered from 2h to 4h before operation. The group did not place any medication before surgery. Results (1) cervical dilatation vaginal misoprostol group (experimental group 1 and group 2) compared with the control group cervical dilatation difference was statistically significant (P <0.05), and vaginal misoprostol 400ug more 200ug cervical dilatation better (P <0.05) :( 2) vaginal misoprostol group operation time, blood loss were less than the control group, the difference was statistically significant (P <0.05), and surgical complications There was no difference between the experimental group 1 and experimental group 2 drug side effects no difference. Conclusions Misdiagnosis of cervical misoprostol before vaginal placement is effective in abortion, and 400 ug is suitable dose for its safe use and worth to be popularized.