替加氟是一种转化为5-氟尿嘧啶的口服化疗前药,主要通过抑制胸苷酸合酶激活并杀死肿瘤细胞.本研究通过取代、水解、缩合合成了20种新的含氨基酸酯基团的替加氟衍生物,并通过1H NMR、13C NMR和H RMS对其结构进行确证,并研究了它们对肿瘤细胞生长抑制作用,结果表明某些化合物有较好的抗肿瘤活性.“,”As an oral chemotherapy prodrug,tegafur,can be converted to 5-fluorouracil,which is activated to kill tumor cells mainly by the inhibition of thymidylate synthase.In the present study,we synthesized 20 new tegafur derivatives containing amino acid ester groups by substitution,hydrolysis,and condensation.Their structures were confirmed by 1H NMR,13C NMR,and H RMS,and their inhibitory effects on tumor cell growth were studied.The results showed that some of the compounds had good anti-tumor activity.