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对56例未经治疗的急性淋巴细胞白血病(ALL)患者外周血淋巴细胞进行了绵羊红细胞(SE)与猴红细胞(RhE)的自然玫瑰花形成及 EA(抗体包被牛红细胞)和 EAC(抗体和补体包被的牛红细胞)玫瑰花形成的研究。在42例儿童病例中19例的淋巴母细胞百分率>50%,其中4例 E一玫瑰花成花细胞(E-RFC)>49%,被归为 T 细胞型白血病,其余15例为 N 细胞型(E-RFC<30%;EA-和 EAC-RFC<10%)。外周血淋巴母细胞低于4.0%者23例未能分类。成年病例中28.5%为 T-细胞型,69.2%为 N-细胞型,1例成人患者无 E-玫瑰花形成,而 EA 和 EAC 玫瑰花分别为40%和31%,被划为 B 型。N-ALL 儿童患者的 RhE-RFC 高于 T-ALL,据此我们认为 RhE 玫瑰花形成可能在 ALL 免疫学分型中具有某些特别意义。
Peripheral blood lymphocytes from 56 patients with untreated acute lymphoblastic leukemia (ALL) were subjected to natural rosette formation of sheep erythrocytes (SE) and monkey erythrocytes (RhE), and the formation of EA (antibody-coated bovine red blood cells) and EAC And complement-coated bovine erythrocytes) rose formation. Of the 42 children, 19 had a lymphoblastic percentage of> 50%, of which 4 were E-RFC> 49%, classified as T-cell leukemia and the remaining 15 as N-cell (E-RFC <30%; EA- and EAC-RFC <10%). Less than 4.0% of peripheral blood lymphoblast cells 23 cases failed to be classified. Of the adult cases, 28.5% were T-cell type, 69.2% were N-cell type and 1 adult had no form of E-rose, whereas EA and EAC rose were 40% and 31%, respectively, classified as Type B. RhE-RFC in pediatric patients with N-ALL is higher than that of T-ALL, so we think that the formation of RhE rosette may have some special significance in ALL immunological typing.