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目的 :观察重组人生长激素 (rhGH)辅助治疗肝硬化的临床效果。方法 :将 2 2例肝硬化患者配对分成观察组与对照组 ,两组均常规保肝及对症支持治疗 ,观察组加用rhGH 4U ,3次 /周 ,疗程 2个月。结果 :观察组有改善症状、消除腹水等效果 ,患者外周血红细胞、白细胞、血小板及血清白蛋白水平均显著上升 ,尿素氮、肌酐水平逐渐下降 ,未出现肝肾综合征及肝脑综合征病例。结论 :短期协用hGH治疗肝炎后肝硬化 (失代偿期 )有一定近期效果 ,可防止或延缓肝肾综合征、肝脑综合征的发生。
Objective: To observe the clinical effect of recombinant human growth hormone (rhGH) adjuvant treatment of liver cirrhosis. Methods: Twenty-two patients with cirrhosis were divided into observation group and control group. Both groups were given routine hepatoprotective and symptomatic supportive therapy. The observation group was treated with rhGH 4U for 3 times a week for 2 months. Results: The observation group had the following symptoms: improvement of symptoms and elimination of ascites. The levels of peripheral blood red blood cells, white blood cells, platelets and serum albumin in the observation group increased significantly, while the level of urea nitrogen and creatinine gradually decreased. There were no hepatorenal syndrome and liver-brain syndrome cases . Conclusion: Short-term use of hGH in the treatment of posthepatitic cirrhosis (decompensation) has some immediate effect, to prevent or delay the occurrence of hepatorenal syndrome, liver and brain syndrome.