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目的:研究ACEI对慢性肾功能衰竭大鼠肾小球硬化进程的延缓作用.方法:将动物分为正常对照组(N组)、慢性肾衰疾病组(D组)、苯那普利早期治疗组(ET组)及晚期治疗组(LT组).检测各组大鼠的BUN、Cr、TP/24h和MAP水平以及肾小球平均截面积和平均体积,并用光镜和电镜观察肾脏的病理学改变.结果:ET组大鼠BUN、Cr、TP/24h以及肾小球平均截面积和平均体积均显著低于D组和LT组;LT组仅前三项指标水平较D组明显下降.病理学检查D组可见肾小球体积增大,呈局灶截段性硬化,系膜增生,间质纤维化:ET组肾脏病理损伤明显减轻,;LT组肾脏病理损伤轻微减轻,较D组有所下降,但差异无显著性.结论:早期给予苯那普利治疗能有效延缓慢性肾衰肾小球硬化的进程,而晚期苯那普利治疗虽能一定程度地改善肾功能和蛋白尿,但对慢性肾衰肾小球硬化的进程并无明显延缓作用.
Objective: To study the delaying effect of ACEI on glomerulosclerosis in rats with chronic renal failure.Methods: The animals were divided into normal control group (N group), chronic renal failure group (D group), benazepril early treatment (ET group) and the late treatment group (LT group). The levels of BUN, Cr, TP / 24h and MAP, mean glomerular cross-sectional area and mean volume of the rats in each group were measured. Neutrophil influx and liver damage were observed.Results: The mean cross-sectional area and average volume of BUN, Cr, TP / 24h, and glomerular in ET group were significantly lower than those in D group and LT group, while only the first three indexes in LT group were significantly lower than those in D group. Pathological examination D group showed increased glomerular volume, showed focal truncal sclerosis, mesangial proliferation, interstitial fibrosis: ET group, renal pathological lesions were significantly reduced; LT group, renal pathological lesion slightly reduced, compared with the D group But the difference was not significant.Conclusion: The early administration of benazepril can effectively delay the progress of glomerulosclerosis in chronic renal failure, while the late benazepril treatment can improve renal function and proteinuria to a certain extent , But no significant delay in the process of glomerulosclerosis in chronic renal failure.