内皮素是迄今所知最强的缩血管物质。妊高征中内皮素继内皮细胞损伤后过量释放,一方面参与妊高征者心血管损伤后修复与重建的保护性机制;另一方面导致全身小血管痉挛,水钠潴留和Ca~(++)代谢异常等病理改变,给机体造成不利影响。内皮素是在妊高征发病机制中起主要作用的物质之一,测定血浆内皮素水平有助于妊高征的诊断和鉴别诊断。 Endothelin is by far the strongest vasoconstrictor. Endothelin in PIH is over released after endothelial cell injury. On the one hand, it is involved in the protective and repair mechanisms of cardiovascular diseases after PIH. On the other hand, it leads to systemic vasospasm, Shuinazhulian and Ca ~ (++) Metabolic abnormalities and other pathological changes, to adversely affect the body. Endothelin is one of the most important substances in the pathogenesis of PIH. Determining plasma endothelin may contribute to the diagnosis and differential diagnosis of PIH.