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目的评价去甲去氢长春碱（诺维本，ＮＶＢ）对非小细胞肺癌（ＮＳＣＬＣ）的治疗作用。方法采用诺维本为主药的联合方案治疗非小细胞肺癌４８例，均为初治患者，均经细胞学或病理证实。结果本组４８例中，没有完全缓解病例，部分缓解２０例，有效率为４１．７％，其中腺癌有效率为５３．５％，鳞癌有效率为２５．０％，其差异有显著性。ＮＰ方案：诺维本（ＮＶＢ）＋顺铂（ＰＤＤ）治疗２０例，有效率为４０．０％；ＮＩ方案：ＮＶＢ＋ＩＦＯ（异环磷酰胺）治疗２８例，有效率为４２．８％，两方案差异无显著性。它不仅能使肿块缩小、缓解症状，而且对骨转移性疼痛及溶骨性破坏疗效更好。对肺鳞癌加上放疗，将获得更好的效果。主要毒性为骨髓抑制及消化道反应。结论ＮＰ或ＮＩ方案是治疗非小细胞肺癌，尤其是合并骨转移者较为理想的方案。
Objective To evaluate the therapeutic effect of norvindicarbine (Novobine, NVB) on non-small cell lung cancer (NSCLC). Methods 48 patients with non-small cell lung cancer were treated with the combination of Nobiben as the main drug. All patients were initially treated and confirmed by cytology or pathology. Results Of the 48 patients in this group, there were no complete remissions and partial remission in 20 patients. The effective rate was 41.7%. The effective rate of adenocarcinoma was 53.5% and the effective rate of squamous cell carcinoma was 25.0%. The difference was significant. Sex. NP protocol: 20 cases of NVB + cisplatin (PDD) treatment, the effective rate was 40.0%; NI program: NVB + IFO (ifosfamide) treatment in 28 cases, the effective rate was 42.8%, two There was no significant difference in the program. It can not only reduce the size of the tumor, relieve the symptoms, but also have a better effect on bone metastatic pain and osteolytic destruction. For squamous cell carcinoma of the lung plus radiotherapy, better results will be obtained. The main toxicity is myelosuppression and gastrointestinal reactions. Conclusion The NP or NI regimen is an ideal treatment for non-small cell lung cancer, especially those with bone metastasis.