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病例与方法:515例经内镜证实且病史在3个月以上的反流性食管炎患者,年龄18岁以上。随机分为3组:服用尼扎替丁(nizatidine)150毫克组和300毫克组(均每日2次)及安慰剂组,分别为169、168和178例。共治疗6周。在进入研究时、3周及6周均行内镜检查。主要有效指标是内镜下食管炎愈合。
Cases and Methods: 515 cases of endoscopic confirmed history and more than 3 months in patients with reflux esophagitis, aged 18 years of age or older. Patients were randomized into 3 groups: nizatidine 150 mg and 300 mg twice daily, and placebo, respectively 169, 168 and 178. A total of 6 weeks treatment. At entry into the study, endoscopy was performed at 3 and 6 weeks. The main effective indicator is endoscopic esophagitis healing.