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探讨β -TCP的降解率是否可以影响rhBMP -2的诱导成骨量。将不同降解率的β -TCP1和β-TCP2分别与rhBMP -2复合制备成不同降解率的两种复合物 ,β -TCP1 /rhBMP -2和β -TCP2 /rhBMP -2。然后分别种植于小鼠股部肌袋中。种植后分别进行组织学检查、组织形态计量、碱性磷酸酶和降解量测定。两种复合物种植后均有软骨和骨形成 ,成骨量随时间推移而增加。但是 ,种植后 8周时β-TCP1 /rhBMP -2组成骨量显著高于β-TCP2 /rhBMP -2组 (P <0 .0 5)。种植后 4周以前两组的ALP水平均随时间推移而升高 (P <0 .0 5) ,但是 ,在 4～ 8周间则无明显差异。此外 ,种植后 8周时β -TCP1 /rhBMP -2的降解量显著高于β -TCP2 /rhBMP -2 (P<0 .0 5)。β -TCP的降解率可以影响BMP的诱导成骨量。
To investigate whether the degradation rate of β-TCP can affect rhBMP-2 induced osteogenesis. The two compounds with different degradation rates, β-TCP1 / rhBMP -2 and β-TCP2 / rhBMP -2, were prepared by complexing rhBMP-2 and β-TCP1 and β-TCP2 with different degradation rates. Then were planted in the femoral muscle bags of mice. After planting, histological examination, histomorphometry, alkaline phosphatase and degradation were measured. Cartilage and bone were formed after both composites were planted, and the amount of bone formation increased over time. However, the bone mass of β-TCP1 / rhBMP-2 at 8 weeks after planting was significantly higher than that of β-TCP2 / rhBMP-2 group (P <0.05). The levels of ALP in both groups increased 4 weeks after planting with time (P <0. 05), however, there was no significant difference between 4 and 8 weeks. In addition, the amount of β-TCP1 / rhBMP-2 degradation was significantly higher than that of β-TCP2 / rhBMP-2 at 8 weeks after planting (P <0.05). The degradation rate of β-TCP can affect BMP-induced osteogenesis.