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半乳糖凝集素3(Gal-3)是半乳糖凝集素家族成员之一,它是半乳糖凝集素家族中唯一的嵌合型凝集素,存在于正常细胞和肿瘤细胞的胞核、胞质和细胞外基质中,能调节树突状细胞(DC)和T淋巴细胞的免疫功能,调节机体免疫应答和炎症反应。研究发现DC分泌Gal-3具有抑制自身凋亡、调节细胞因子生成以及调节T细胞应答等多种功能。同时Gal-3位于胞外和胞内对T淋巴细胞分别具有相反作用,胞外Gal-3诱导T细胞凋亡,胞内Gal-3抑制其凋亡。此外Gal-3在调节炎症反应中的起重要作用。
Galectin-3 (Gal-3), a member of the galectin family, is the only chimeric lectin found in the galectin family and exists in the nucleus, cytoplasm, and cytoplasm of normal and tumor cells Extracellular matrix, can regulate the immune function of dendritic cells (DCs) and T lymphocytes, regulate the body’s immune response and inflammatory response. The study found that DC secreting Gal-3 can inhibit its own apoptosis, regulate cytokine production and regulate T cell responses and other functions. In the meantime, Gal-3 was located in extracellular and intracellular sites, respectively, which had the opposite effect on T lymphocytes. The extracellular Gal-3 induced the apoptosis of T cells and the intracellular Gal-3 inhibited its apoptosis. In addition Gal-3 plays an important role in the regulation of inflammatory response.