对外周血淋巴细胞或羊膜细胞进行高分辨染色体分析,可能检查微小的染色体结构畸变,而此种畸变如用常规中期染色体分析方法是难以发现的.涉及微小染色体片段的家族性易位,常常在不平衡后代出生后发现,由此而确诊并进而可对这些高风险家族进行羊膜穿刺.由于绒毛膜活检技术的发展,对一些高风险家族,已经可以在妊娠最初三个月进行产前诊断.为了能对这种家族在最初三个月进行产前诊断,作者通过用FdU、BrdU及溴乙啶 High-resolution chromosomal analysis of peripheral blood lymphocytes or amniotic cells may examine microscopic structural aberrations of chromosomes that are difficult to detect with conventional metaphase chromosome analysis Familial translocations involving minute chromosomal segments are often found in After birth, unbalanced offspring were found to be diagnosed and, as a result, amniocentesis were performed on these high-risk families, and as a result of the development of chorionic villus techniques, some high-risk families have been able to make prenatal diagnosis in the first trimester of pregnancy. In order to conduct a prenatal diagnosis of this family in the first trimester, the authors used FdU, BrdU and ethidium bromide