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肝脏是血小板生成素 (ＴＰＯ)生成的主要脏器 ,ＴＰＯ调节巨核细胞和血小板生成的作用。为了研究受损ＴＰＯ基因表达在肝功能衰竭患儿血小板减少发病机理中的作用 ,作者应用肝ＲＮＡ的逆转录———聚合酶链反应 (ＲＴ ＰＣＲ)对肝硬化或急性肝衰 (ＡＬＦ)患儿肝组织中的ＴＰＯ
The liver is a major organ produced by thrombopoietin (TPO) and TPO regulates the production of megakaryocytes and platelets. In order to investigate the role of impaired TPO gene expression in the pathogenesis of thrombocytopenia in children with liver failure, the authors used reverse transcription-polymerase chain reaction (RT-PCR) of liver RNA in patients with cirrhosis or acute liver failure (ALF) TPO in liver tissue