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棉酚可导致许多种类的雄性动物及男子不育,目前正在推荐作为人类避孕药物应用。该药能影响精子发生的各个不同阶段,包括精母细胞和精子细胞,且对睾丸和附睾中的精子也显示出有影响。对精子尾的作用可能是该药对精子发生早期阶段时的继发性损伤,但作用模式尚不清楚,可能是通过对氧化磷酸化或胚细胞中的乳酸脱氢酶作用所引起。该化合物对支持细胞也可能有影响。作者报告检测了雄大鼠给予棉酚后不同时期中睾丸细胞的超微结构。睾丸细胞在给药后14天已显示出损伤。支持细胞有些已变成空泡。胚细胞,特别是精子细胞和一些精母细胞脱落。精子细胞的损伤处主要在小管部位。且精子细胞中的线粒体肿胀和缺脊。一些精子尾轴也遭损伤。存于附睾尾中的精子损伤更快。给药后5天就已出现,损伤类型同精子细胞。给药后25天可看到更进一步的损坏,包
Gossypol causes many types of male and male infertility and is currently being recommended as a human contraceptive use. The drug affects various stages of spermatogenesis, including spermatocytes and sperm cells, and also affects sperm in the testes and epididymis. The effect on the sperm tail may be secondary to this drug’s effect on early stages of spermatogenesis, but the mode of action is unclear, possibly through oxidative phosphorylation or lactate dehydrogenase action in the embryo cells. This compound may also have an effect on supporting cells. The authors report testing the ultrastructure of testicular cells in different periods after administration of gossypol in male rats. Testicular cells have shown damage 14 days after dosing. Some supporting cells have become vacuoles. Germ cells, especially sperm cells and some spermatocytes fall off. Sperm cell damage at the small tube site. Mitochondria in sperm cells are swollen and missing. Some sperm sternos have also been damaged. Sperm deposited in the epididymal tail damages faster. 5 days after administration has appeared, the type of injury with sperm cells. 25 days after administration can see further damage, package