在糖尿病患者及糖尿病动物模型中均存在生长激素受体的异常。作为哺乳动物体内生长激素的主要受体,可活化信号转导、促前脂肪细胞分化等,生长激素受体活性和(或)数量的变化对生长激素的功能产生明显的影响。现对生长激素受体的分子结构、组织分布和功能,以及生长激素受体及其亚型与糖尿病及其并发症之间的相互影响进行综述。 Abnormalities in growth hormone receptors exist in both diabetic and diabetic animal models. As the main receptor of growth hormone in mammals, it can activate signal transduction and promote the differentiation of preadipocytes. The changes of growth hormone receptor activity and / or quantity have a significant effect on the growth hormone’s function. The molecular structure, tissue distribution and function of growth hormone receptors, and the interaction between growth hormone receptors and their subtypes and diabetes mellitus and their complications are reviewed.