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目的 探讨同型半胱氨酸（Hcy）水平与多囊卵巢综合症（PCOS）、早期妊娠流产（EPL）的相关性。方法 收集PCOS患者123例，其中既往有一次或一次以上12周内流产的患者65例（PCOS流产组），有正常妊娠史的患者58例（PCOS非流产组），另外选取同期既往有一次或一次以上12周内流产并排除PCOS的患者147例（非PCOS流产组）。采用循环酶法检测三组 Hcy 水平并比较。结果 PCOS 流产组 Hcy 水平（14．69±3．91）明显高于PCOS非流产组（11．67±2．93）和非PCOS组流产组（13．14 ± 3．37），且非PCOS流产组显著高于PCOS非流产组，其差异均有统计学意义（ P ＜0．05）。结论 高Hcy水平是导致EPL发生的危险因素，可作为预测早期妊娠结局的指标。“,”Objective] To explore the correlation of homocysteine(HCY) level with polycystic ovary syn‐drome(PCOS) and early pregnancy abortion(EPL) .[Methods]Totally 123 patients with PCOS including 65 patients with one or more than one abortion within 12 weeks(PCOS abortion group) and 58 patients with nor‐mal pregnant history(PCOS non‐abortion group) were collected .Other 147 patients with one or more than one abortion within 12 weeks but without PCOS (non‐PCOS abortion group) were selected in the same period . HCY level was detected by enzymatic cycling method and compared among 3 groups .[Results] The level of HCY in PCOS abortion group was obviously higher than that in PCOS non‐abortion group and non‐PCOS abor‐tion group ,and that in non‐PCOS abortion group was markedly higher than that in PCOS non‐abortion group , and there was significant difference( P<0 .05) .[Conclusion]High HCY level is a risk factor for EPL and can be used as the indicator of early pregnancy outcome .