Corwin(ICI 118,587)是一种具有心脏选择性、部份内在拟交感神经活力的口服长效β-肾上腺能激动剂。所谓部份激动剂(Partial agonist)是指同时具有激动和阻断效应的制剂。Corwin 的内在拟交感神经活力为异丙肾上腺素的43％;激动和阻滞的平衡取决于患者的基础交感神经活力。作者在9例有劳力型心绞痛患者中试用Corwin治疗,结 Corwin (ICI 118,587) is an orally active long-acting β-adrenergic agonist with cardiac selectivity and some intrinsic sympathetic activity. Partial agonists are agents that have both agonistic and blocking effects. The inner sympathetic viability of Corwin is 43% of that of isoproterenol; the balance of agitation and retardation depends on the patient’s basal sympathetic activity. The authors tested Corwin in nine patients with labor-type angina and completed the trial