自 1 96 9年Ryard首次将人结肠癌在裸鼠体内移植成功至今 ,该技术及其应用有了飞速的发展。与传统的小鼠肿瘤相比 ,运用人癌裸小鼠移植瘤模型进行抗肿瘤药物药效学评价有以下优点 :(1 )强调药物对实体肿瘤的作用 :(2 )具有更多证实对某一特定人类肿瘤有较强作用的新化合物的机? The technology and its applications have been rapidly developed since Ryard first successfully transplanted human colon cancer in nude mice in 1966. Compared with the traditional mouse tumors, the use of human cancer in nude mice xenograft tumor model pharmacodynamic evaluation has the following advantages: (1) emphasize the role of drugs on solid tumors: (2) have more confirmed that a A specific human tumor has a strong role of the new compound machine?