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癌性胸水是晚期癌症常见的并发症之一,给病人带来一定痛苦,临床上全身用药效果不甚理想,因此,有效地控制癌性胸水对癌症患者生存期的延长和生存质量的改善具有重要的临床意义.本文目的是探讨白细胞介素-2加顺铂胸腔内注射治疗癌性胸水的临床疗效.现报告如下:①一般资料:42例癌性胸水患者中,男36例,女6例,平均年龄59.27±12.42岁,所有患者均经细胞学或组织学确诊,其中肺癌38例(腺癌26例,鳞癌8例,小细胞癌4例),乳腺癌3例,恶性胸膜间皮瘤1例.②治疗方法:经用套管针胸腔穿刺成功后,留置医用硅橡胶管于胸腔内持续引流,将胸水引流完毕,注入白细胞介素-260万～100万U[卫生部批号(97)卫药准字(京远策)S-01号],用生理盐水20ml稀释,然后注入顺铂80～100mg用生理盐水50ml稀释,缓慢注入胸腔,每周1次,2～4周为1疗程.注药后嘱患者反复翻身并作深呼吸运动,以利药物在胸膜腔内均匀分布,同时给予水化利尿,酌情给予抗呕吐治疗.治疗后每周复查1次X线或B超,如发现仍有胸腔积液,可再次用上述方法治疗1次,最多不超过4次.本组治疗1次16例,2次22例,3次3例,4次1例.
Cancerous pleural effusion is one of the common complications of advanced cancer, which brings some pain to the patient. The systemic medication effect is not ideal in clinical practice. Therefore, effective control of cancerous pleural effusion has an effect on prolonging the survival period and improving the quality of life of cancer patients. Important clinical significance. The purpose of this article is to investigate the clinical efficacy of intrapleural injection of interleukin-2 plus cisplatin in the treatment of cancerous pleural effusion. The current report is as follows: 1 General information: Of the 42 patients with cancerous pleural effusion, 36 were male and 6 were female. Cases, mean age 59.27±12.42 years, all patients were diagnosed by cytology or histology, including 38 cases of lung cancer (adenocarcinoma 26 cases, 8 cases of squamous cell carcinoma, 4 cases of small cell carcinoma), 3 cases of breast cancer, malignant pleural 1 case of cutaneous tumor. 2 Treatment: After successful puncture with trocar puncture, indwelling medical silicone rubber tube was continuously drained in the thoracic cavity, drainage of pleural effusion was completed, and interleukin-2,600,000 to 1 million U was injected [[Ministry of Health, Lot No.] (97) Wei Yao Zhunzi (Kyohyo Strategy) No. S-01], diluted with normal saline 20ml, then injected with cisplatin 80 ~ 100mg diluted with normal saline 50ml, slowly injected into the chest, once a week, 2 ~ 4 weeks It is a course of treatment. After injection, the patient repeatedly turns over and takes a deep breathing exercise to facilitate the drug in the pleura. Uniform distribution in the cavity, while giving hydration and diuresis, anti-vomiting treatment as appropriate. After treatment, X-ray or B-ultrasound is reviewed once a week. If there is still pleural effusion, it can be treated once again with the above method, at most not more than 4 times. In this group, 16 cases were treated once, 22 cases were 2 times, 3 cases were 3 times, and 1 case was 4 times.