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该文建立了简便合成2-苯乙烯基-3,5-二乙氧羰基-6-甲基吡啶衍生物的方法。以乙酰乙酸乙酯、甲醛和乙酸铵为初始原料,通过缩合关环和氧化芳香化合成中间体2,6-二甲基-3,5-二乙氧羰基吡啶,再与苯甲醛衍生物在乙酸中回流缩合,合成了9个2-苯乙烯基-3,5-二乙氧羰基-6-甲基吡啶衍生物。通过1HNMR、MS、IR对所合成化合物的结构进行表征。研究了9个吡啶衍生物在不同溶剂中的荧光性质。结果表明:合成的吡啶衍生物在不同溶剂中的最大吸收波长在302~382 nm,发射波长在397~537 nm,摩尔消光系数在1.045×104~4.236×104L/(mol·cm)。
This paper established a simple and convenient method for the synthesis of 2-styryl-3,5-diethoxycarbonyl-6-methylpyridine derivatives. Using ethyl acetoacetate, formaldehyde and ammonium acetate as starting materials, the intermediate 2,6-dimethyl-3,5-diethoxycarbonylpyridine was synthesized by condensation-closing ring and oxidation aromatization, Acetic acid reflux condensation, synthesis of nine 2-styryl-3,5-diethoxycarbonyl-6-methylpyridine derivatives. The structures of the synthesized compounds were characterized by 1H NMR, MS, IR. The fluorescence properties of nine pyridine derivatives in different solvents were studied. The results showed that the maximum absorption wavelength of the synthesized pyridine derivatives was in the range of 302 ~ 382 nm, the emission wavelength was in the range of 397 ~ 537 nm, and the molar extinction coefficient was 1.045 × 104 ~ 4.236 × 104 L / (mol · cm).