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目的评价肾小球滤过率(GFR)评估方程对我国糖尿病慢性肾脏疾病(CKD)患者的适用性。方法选择294例糖尿病患者,用瑞金方程、CG方程、MDRD方程分别预测GFR值,与99mTc-DTPA测得的GFR(sGFR)进行比较。结果 Bland-Altman分析显示瑞金方程估计的eGFR和sGFR的一致性最好,一致性限度为-37.2～50.2,但所有方程估计的eGFR和sGFR的一致性限度均超过事先规定的专业界值。线性回归结果显示,瑞金方程估测的eGFR与X轴的斜率为0.15,与Y轴的截距为-6.52,均比其他方程更小。瑞金方程估测eGFR 15%、30%和50%符合率均较高,且估测eGFR 30%符合率高于70%。3种估算公式受血糖的影响均较小。结论瑞金方程可能更适合我国CKD患者评估GFR。
Objective To evaluate the applicability of glomerular filtration rate (GFR) assessment equation to patients with chronic kidney disease (CKD) in our country. Methods 294 diabetic patients were selected. The GFR values were predicted by the Ruijin equation, CG equation and MDRD equation, respectively, and compared with GFR (sGFR) measured by 99mTc-DTPA. Results The Bland-Altman analysis showed that the agreement between eGFR and sGFR estimated by the Ruijin equation was the best, with a consistency limit of -37.2 to 50.2. However, the eGFR and sGFR consistency limits estimated by all equations exceeded the pre-defined professional values. The linear regression results show that the eGFR estimated by the Ruijin equation has a slope of 0.15 with respect to the X axis and an intercept of -6.52 with the Y axis, all of which are smaller than other equations. The Ruijin equation estimated eGFR 15%, 30% and 50% coincidence rates were high, and the estimated eGFR 30% coincidence rate was higher than 70%. The three kinds of estimation formulas are less affected by blood sugar. Conclusion The Ruijin equation may be more suitable for the assessment of CKD in our country.