同型半胱氨酸硫内酯是氨基酰-tRNA合成酶在编辑或校正过程中形成的同型半胱氨酸反应产物,它可直接或通过蛋白质同型半胱氨酸化损伤内皮细胞。而内皮细胞同型半胱氨酸硫内酯的合成及蛋白质同型半胱氨酸化程度取决于同型半胱氨酸/蛋氨酸、叶酸、高密度脂蛋白等。同型半胱氨酸硫内酯解酶作为体内降解同型半胱氨酸硫内酯的惟一酶类,其活性的高低在与同型半胱氨酸相关的血管病变中可能起重要作用。 Homocysteine ​​Thiolactone is a homocysteine ​​reaction product formed during editing or calibration by aminoacyl-tRNA synthetases that damage endothelial cells either directly or through protein homocysteination. The synthesis of endothelial homocysteine ​​thiolactone and protein homocysteination depends on the degree of homocysteine ​​/ methionine, folic acid, high-density lipoprotein and so on. Homocysteine ​​thiolactolase, the only enzyme that degrades homocysteine ​​thiolactone in vivo, may play an important role in the homocysteine-related vascular pathology.