选健康的Sprag-Dauleg大白鼠80只,体重100～150g,随机分成8组,每组10只,雌雄各半。染毒7个组,对照1个组。取灌胃给药,各组大鼠给药前12小时停止进食,给药后连续观察7天。复方乐果各组剂量分别为146、174、210、252、302、362、434mg/kg体重。对照组每只大鼠灌注1ml蒸馏水。结果求出半数致死剂量(LD_50)为254.4mg/kg(按有效成份计),按商品复方乐果(40%乳剂)计算,LD_50为636mg/kg。其95%可信限为381.7～169.5mg/kg(有效成份计)。据“化学物质急性毒性分级表”(见工业毒理学,上册,第一版,上海人民出版社,1976:5)该药列为中等毒物。如按商品复方乐果(40%乳 Eighty healthy healthy Sprag-Dauleg rats weighing 100-150g were randomly divided into 8 groups with 10 mice in each group, half male and one female. Infected 7 groups, control 1 group. Take gavage, rats in each group before 12 hours to stop eating, continuous observation after 7 days. Compound dimethoate doses were 146,174,210,252,302,362,434 mg / kg body weight. Control rats were perfused with 1 ml of distilled water. As a result, the median lethal dose (LD_50) was 254.4 mg / kg (calculated as active ingredient), and the LD_50 was 636 mg / kg according to the commercial compound dimethoate (40% emulsion). The 95% confidence limit for the 381.7 ~ 169.5mg / kg (active ingredients). According to “Chemical Acute Toxicity Scale” (see Industrial Toxicology, the first edition, the first edition, Shanghai People’s Publishing House, 1976: 5) classified as moderate poison. Such as by the product compound dimethoate (40% milk