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目的： 探讨灵芝复康宝抗肿瘤作用的免疫学机理。方法： 采用 Ｅ Ｌ Ｉ Ｓ Ａ 法则定不同剂量芝复康宝对 Ｓ１８０ 荷瘤小鼠血清 Ｉ Ｌ２ 、 Ｔ Ｎ Ｆα含量的影响。结果：小剂量组（０ ．５ ｍｇ／ｋｇ 体重） 血清 Ｉ Ｌ２ 和 Ｔ Ｎ Ｆα水平明显高于对照组（ Ｐ＜ ０．０５） 。结论：小剂量的灵芝复康宝对荷瘤鼠 Ｉ Ｌ２ 和 Ｔ Ｎ Ｆα均有一定的诱生作用，提示小剂量的灵芝复康宝可能通过调节宿主 Ｂ Ｒ Ｍ（ｂｉｏｌｏｇｉｃａｌｒｅｓｐｏｎｓｅ ｍｏｄｉｆｉｅｒｓ ， Ｂ Ｒ Ｍ） 系统而发挥其抑制肿瘤的作用。
Objective: To investigate the immunological mechanism of Ganoderma lucidum Fukangbao anti-tumor effect. METHODS: The effects of different doses of Zhifu Kangbao on serum I L 2 and T N F α levels in S180 tumor-bearing mice were determined by E L I S A method. Results: The levels of serum I L 2 and T N F α in the low-dose group (0.5 mg/kg body weight) were significantly higher than those in the control group (P < 0.05). Conclusion: The low dose of Ganoderma lucidum Fukangbao has a certain induction effect on tumor-bearing mice I L 2 and T N F α, suggesting that small doses of Ganoderma lucidum Fukang Po may by regulating the host B R M (biologicalresponse modifiers, B R M) System exerts its effect of suppressing tumors.