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通过研究肿瘤抑制率、脾脏指数和胸腺指数、肿瘤切片细胞的形态以及血清中影响因子白细胞介素‐2、肿瘤坏死因子‐α、干扰素‐γ、丙二醛、超氧化物歧化酶、过氧化氢酶和谷胱甘肽过氧化物酶等指标的变化来考察玉木耳Auricularia cornea提取物体内抗肿瘤作用及其作用机理。结果表明,乙酸乙酯高、低剂量组的抑瘤效果较好分别为39.9%和37.5%;HE染色切片观察各组均出现肿瘤坏死区,高剂量出血坏死面积较低剂量大;与模型组比较,乙酸乙酯组白细胞介素‐2、肿瘤坏死因子‐α、干扰素‐γ含量升高,具有较好的免疫作用。玉木耳提取物具有明显的抗肿瘤作用,其中乙酸乙酯高、低剂量组的抗肿瘤作用最显著,与其增强免疫作用有一定关系。
Through the study of tumor inhibition rate, spleen index and thymus index, the shape of the tumor section cells and the influence factors of serum interleukin-2, tumor necrosis factor-α, interferon-γ, malondialdehyde, superoxide dismutase Catalase and glutathione peroxidase and other indicators to investigate the Tamarix Auricularia cornea extract in vivo anti-tumor effect and its mechanism of action. The results showed that the anti-tumor effect of high-dose and low-dose ethyl acetate groups were 39.9% and 37.5%, respectively. HE staining showed tumor necrosis in all groups, Compared with ethyl acetate group, interleukin-2, tumor necrosis factor-α, interferon-γ content increased, with good immune function. Tung fungus extract has obvious anti-tumor effects, of which ethyl acetate high and low doses of the most significant anti-tumor effect, and its enhanced immune function have a certain relationship.