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本文介绍了一种测定片剂及胶囊剂中左旋多巴、左旋多巴-卡别多巴的快速反相高效液相色谱法。本法可分离左旋多巴中的杂质3-(3,4,6—三羟基苯基)丙氨酸及甲氧基酪氨酸以及卡别多巴中的杂质甲基多巴和3-0-甲基卡别多巴。流动相为3%醋酸,在280nm 波长处检测。本法线性范围浓度:左旋多巴0.05～0.40mg/ml;卡别多巴0.01～0.06mg/ml;3-(3,4,6三羟基苯基)丙氨酸0.9～12.8μg/ml;甲基多巴0.7～3.1μg/ml;甲氧基酪氨酸5～20μg/ml,甲基卡别多巴0.5～3.3μg/ml。模拟片剂平均
This article describes a rapid determination of levodopa tablets, capsules and levodopa - carbidopa fast reversed-phase high performance liquid chromatography. This method separates the impurities 3- (3,4,6-trihydroxyphenyl) alanine and methyloxytyrosine in levodopa and the impurities methyldopa and 3-0 in cardiopodopa - Methyl card Vendome. The mobile phase is 3% acetic acid and is detected at a wavelength of 280 nm. The linear range of the present concentration: levodopa 0.05 ~ 0.40mg / ml; catopoeba 0.01 ~ 0.06mg / ml; 3- (3,4,6-trihydroxyphenyl) alanine 0.9 ~ 12.8μg / ml; Methyldopa 0.7 ~ 3.1μg / ml; methyloxy tyrosine 5 ~ 20μg / ml, methyl card and dopa 0.5 ~ 3.3μg / ml. Simulated tablets average