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目的：探讨地氟醚是否具有诱导心肌预适应作用。方法：ＳＤ 大鼠离体心脏采用Ｌａｎｇｅｎｄｏｒｆｆ 装置灌流。２１只大鼠随机分成对照组（Ｃ组） 、地氟醚组（Ｄ组） 和缺血预处理组（ＩＰ组） ，连续监测ＨＲ，左室内压（ＬＶＰ）及左室内压上升和下降最大速率（ ±ｄｐ／ｄｔｍａｘ）。实验结束时取心肌组织观察其超微结构变化。结果：Ｄ 组和ＩＰ组ＬＶＰ、±ｄｐ／ｄｔｍａｘ 恢复明显优于Ｃ组（ Ｐ＜ ０－０５） ，心肌超微结构损害比Ｃ组轻。Ｄ组和ＩＰ组心功能恢复无统计学差异，心肌结构改变接近。结论：地氟醚预处理模拟缺血预适应可保护缺血再灌注心肌
Objective: To investigate whether desflurane can induce myocardial preconditioning. Methods: The isolated rat heart was perfused with Langendorff apparatus. Twenty-one rats were randomly divided into control group (C group), desflurane group (D group) and ischemic preconditioning group (IP group). HR, left ventricular pressure (LVP) and left ventricular pressure Rate (± dp / dtmax). Myocardial tissue was taken at the end of the experiment to observe its ultrastructure changes. Results: The recovery of LVP and ± dp / dt max in group D and group IP was significantly better than that in group C (P <0-05). The damage of myocardial ultrastructure was lighter than that in group C. There was no significant difference in cardiac function recovery between D group and IP group, and the change of myocardial structure was similar. Conclusion: Desflurane preconditioning can protect ischemic-reperfused myocardium