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目的:阐明白介素-18(IL-18)与缺血性脑卒中(IS)的相关性。方法:采用病例对照研究方法,对IS病例组423例和对照组384名(两组研究对象年龄、性别匹配,均为中国汉族人群)应用聚合酶链反应技术(PCR)及凝胶电泳技术进行IL-18基因启动子-607 C/A(rs1946518)分析。用Logistic回归分析去除混杂因素的影响,分析其基因型、等位基因型与缺血性脑卒中发病的相关性。结果:-607C等位基因型与IS发病有相关性,是IS重要的危险因素(OR=1.358,P=0.002)。结论:中国汉族人群中,IL-18基因启动子的多态性可能与IS的发病有关,等位基因型-607C可能增加IS的发病风险。
Objective: To clarify the correlation between interleukin-18 (IL-18) and ischemic stroke (IS). Methods: A case-control study was conducted in which 423 cases of IS and 384 cases of control (age and gender matched in both groups were Chinese Han population) were studied by polymerase chain reaction (PCR) and gel electrophoresis IL-18 gene promoter -607 C / A (rs1946518) analysis. Logistic regression analysis was used to analyze the influence of confounding factors and to analyze the association between genotype, allele and ischemic stroke. RESULTS: The -607C allele was associated with the pathogenesis of IS and was an important risk factor for IS (OR = 1.358, P = 0.002). CONCLUSION: Polymorphism of IL-18 gene promoter in Chinese Han population may be related to the pathogenesis of IS, and allele-607C may increase the risk of IS.