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目的探讨慢性阻塞性肺疾病(COPD)急性加重期血清胱抑素C(Cys C)的变化及意义。方法 COPD急性加重期患者42例作为观察组,50例本院在院及退休职工作为对照组,测量Cys C、肌酐(Cr),对测量结果进行比较,同时测量C反应蛋白(CRP),分析二者相关性。结果 COPD急性加重时测量的Cys C结果与对照组和缓解后测量的结果比较差异有统计学意义(P<0.01),而患者Cr与对照组和缓解后比较差异无统计学意义(P>0.05),急性加重时测量的Cys C结果与CRP呈正相关(r=0.5979,P<0.05)。结论 Cys C可能参与了COPD急性加重的过程,检测结果与COPD患者病情发展密切相关。
Objective To investigate the changes and clinical significance of serum cystatin C (Cys C) in acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods 42 patients with acute exacerbation of COPD were selected as observation group and 50 hospitalized and retired workers in our hospital as control group. Cys C and creatinine (Cr) were measured. The levels of C-reactive protein (CRP) The correlation between the two. Results The results of Cys C measured in acute exacerbation of COPD were significantly different from those of control group and post-remission measurement (P <0.01), but there was no significant difference in Cr between the control group and the control group after remission (P> 0.05 ), Cys C was positively correlated with CRP in acute exacerbation (r = 0.5979, P <0.05). Conclusion Cys C may be involved in the process of acute exacerbation of COPD. The detection results are closely related to the progression of COPD.