由于中心体在肿瘤发生中潜在的重要作用而逐渐受到人们的关注 ,本文除了对这一细胞器作简要介绍外 ,主要综述了在肿瘤发生过程中中心体复制的调节及数目稳定的控制 ,中心体的扩增与细胞循环调节之间的联系 ,以及中心体异常与染色体不稳定和肿瘤发生的相关性。从中心体异常入手探索肿瘤发生机制、诊断及治疗的有效途径 ,可能会为攻克肿瘤这一顽症开辟一条崭新的途径。 Because of the central role of centrosome in tumorigenesis, it is gradually receiving the attention of people. In addition to brief introduction of this organelle, this article mainly reviews the regulation of centrosome replication and the control of the number stability in the process of tumorigenesis. And the relationship between centrosome abnormalities and chromosomal instability and tumorigenesis. To explore the mechanism of tumor pathogenesis, diagnosis and treatment from the abnormal center may be a new way to overcome the chronic disease of tumor.